张凌博士，男，澳门新浦新京8455com(中国)有限公司研究员，医用高分子材料及人工器官系（生物医学工程方向）成员。2018年入职，2020年获自科委优秀青年人才基金研究支持。工作主要涉及高分子与生物学交叉领域，包括材料-生物相互作用机理及后续生物效应、小体积材料的跨膜运输和信号、新型药物传递材料、高分子及纳米材料的毒性研究等等。此外，对生物信息学、计算数学、生物物理等学科在相关研究中得应用也有浓厚兴趣。近年在Current Biology, AFM, JCR, Nano Research, Biomaterial等杂志上发表论文。

个人简介

2020年9月 至今，澳门新浦新京8455com(中国)有限公司，研究员

2018年9月— 2020年8月，澳门新浦新京8455com(中国)有限公司，特聘副研究员

2011年3月—2018年6月，英国曼彻斯特大员工物、医药及健康学院，博士后，合作导师：Philip Woodman教授，Victoria Allan教授，Alan Roseman博士。

2006年9月—2011年3月，英国曼彻斯特大员工命科学院，硕士及博士，导师：Philip Woodman教授，Hilary Ashe博士，Richard Kamerer博士。

2002年9月—2006年6月，复旦大员工命科学院，学士，导师：金力教授。

研究方向

1. 高分子等材料与生物系统微观相互作用

2. 脂质体及其他纳米材料递送系统

3. 微材料的跨膜运输以及跨膜信号系统

4. 结合组学、数学模型等的生物-纳米系统研究

常年招聘材料、生物、医药、数学、物理背景的研究生（包括各种联合培养形式）和博后，同时欢迎公司各学科背景的本科同学，以及成都地区其他院校本科生到实验室做毕业论文或利用业余时间从事科研项目。此外，我们将为课题组成员以后的留学、出国交流及保研等方面尽量提供推荐和帮助。欢迎感兴趣的同学与我直接联系。邮箱: zhangling83@scu.edu.cn地址：公司望江校区澳门新浦新京8455com原主楼405/附楼306。

2018年以来发表论文：

2022:

1.Recent Advances in Delivery Systems for Genetic and Other Novel Vaccines. Shiqi Huang, Yining Zhu, Ling Zhang*, Zhirong Zhang. Advanced Materials. 2022, 2107946. Doi: 10.1002/adma.202107946

2.Co-delivery of TRAIL and paclitaxel by fibronectin-targeting liposomal nanodisk for effective lung melanoma metastasis treatment. Shiqi Huang, Lang Deng, Hanming Zhang, Luyao Wang, Yicong Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang*. Nano Research. 2022, 15(1): 728–73. Doi: 10.1007/s12274-021-3553-2

3.Targeted delivery of celastrol to glomerular endothelium and podocytes for chronic kidney disease treatment. Qingsi Wu, Jiading Wang, Yuanfang Wang, Ling Xiang, Yulu Tan, Jiaxing Feng, Zhirong Zhang*, Ling Zhang*. Nano Research. 2022, 15:3556–3568. Doi: 10.1007/s12274-021-3894-x

4.A Dual-responsive nanoplatform with feedback amplification improves antitumor efficacy of photodynamic therapy. Yuan Xue, Shuting Bai, Leilei Wang, Shi Luo, Zhirong Zhang, Tao Gong, Ling Zhang*. Nanoscale. 2022, 14:2758-2770. Doi: 10.1039/D1NR06875J

2021：

1.Novel Brain-targeting 3-n-butylphthalide Prodrugs for Ischemic Stroke Treatment.Honglin Xiang, Qiang Zhang, Yikun Han, Lan Yang, Yan Zhang, Qiang Liu, Zhirong Zhang*, LingZhang*. Journal of Controlled Release. 2021 Jul 10; 335:498-514. Doi:10.1016/j.jconrel.2021.05.045

2.Collagenase-loaded pH-sensitive nanocarriers efficiently remodeled tumor stroma matrixes and improved the enrichment of nanomedicines. Jiading Wang, Qingsi Wu, Yuanfang Wang, Ling Xiang, Jiaxing Feng, Zhaojie Zhou, Qiang Fu*, Ling Zhang * . Nanoscale. 2021 May 18;13:9402-9414. Doi: 10.1039/D1NR00950H

3.Endosomal recycling tubule scission and integrin recycling involve the membrane curvature supporting protein LITAF. Lydia Wunderley#, Ling Zhang#, Rebecca Yarwood, Wenxia Qin, Martin Lowe, Philip Woodman*. Journal of Cell Science. 2021 134 (15): jcs258549. Doi:https://doi.org/10.1242/jcs.258549

4.OX40L blockade cellular nanovesicles for autoimmune diseases therapy.Yu Fu, Leilei Wang, Wei Liu, Lan Yang, Lin Li, Luyao Wang, Xun Sun, Zhirong Zhang, Qing Lin, Ling Zhang*.Journal of Controlled Release. 2021 337:557-570. Doi: 10.1016/j.jconrel.2021.08.008

5.Enhanced anti-metastatic therapy with down-regulation of heparinase expression by ROS-responsive micellar nanoparticles. Yicong Zhang, Yuai Li, Shiqi Huang, Hanming Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang*. Nanoscale. 2021, 13, 15267. Doi: 10.1039/D1NR02964A

6.Multifunctional size-expandable nanomedicines enhance tumor accumulation and penetration for synergistic chemo-photothermal therapy. Yuai Li, Lan Yang, Xiaomin Xu, Min Li, Yicong Zhang, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang*. ACS Applied Materials & Interfaces. 2021, 13, 39, 46361–46374. Doi: 10.1021/acsami.1c14170

7.An exosome-mimicking membrane hybrid nanoplatform for targeted treatment toward Kras-mutant pancreatic carcinoma.Lang Deng,Hanming Zhang,Yu Zhang,Shi Luo,Zhengwu Du,Qing Lin,Zhirong Zhang,Ling Zhang*. Biomaterials Science. 2021,9, 5599-5611. Doi: 10.1039/D1BM00446H

2020：

1.The pore size of mesoporous silica nanoparticles regulates their antigen delivery efficiency. Xiaoyu Hong, Xiaofang Zhong, Guangsheng Du, Yingying Hou, Yunting Zhang, Zhirong Zhang, Tao Gong, Ling Zhang*, Xun Sun*. Science Advances. 2020 Jun 19;6(25):eaaz4462. doi: 10.1126/sciadv.aaz4462

2.Target delivering paclitaxel by ferritin heavy chain nanocages for glioma treatment. Wei Liu, Qing Lin, Yu Fu, Shiqi Huang, Chengqi Guo, Lin Li, Leilei Wang, Zhirong Zhang, Ling Zhang*. Journal of Controlled Release. 2020 Jul 10;323:191-202. doi: 10.1016/j.jconrel.2019.12.010

3.Co-delivery of antigen and dual adjuvants by aluminum hydroxide nanoparticles for enhanced immune responses. Yingying Hou, Ying Wang, Yao Tang, Zixuan Zhou, Lu Tan, Tao Gong, Ling Zhang*, Xun Sun*. Journal of Controlled Release. 2020 Oct 10;326:120-130. doi: 10.1016/j.jconrel.2020.06.021

4.Tailored Elasticity Combined with Biomimetic Surface Promotes Nanoparticle Transcytosis to Overcome Mucosal Epithelial Barrier. Yaxian Zheng, Liyun Xing, Liqiang Chen, Rui Zhou, Jiawei Wu, Xi Zhu, Lian Li, Yucheng Xiang, Ruinan Wu, Ling Zhang*, Yuan Huang*. Biomaterials. 2020 Dec;262:120323. doi: 10.1016/j.biomaterials.2020.120323.

5.Co-delivery of p38α MAPK and p65 siRNA by novel liposomal glomerulus-targeting nano carriers for effective immunoglobulin a nephropathy treatment.Yuanfang Wang, Qingsi Wu, Jiading Wang, Lin Li, Xun Sun, Zhirong Zhang, Ling Zhang*.Journal of Controlled Release. 2020 Apr 10;320:457-468. doi: 10.1016/j.jconrel.2020.01.024.

6.Improved melanoma suppression with target-delivered TRAIL and Paclitaxel by a multifunctional nanocarrier. Shiqi Huang, Yicong Zhang, Luyao Wang, Wei Liu, Linyu Xiao, Qing Lin, Tao Gong, Xun Sun, Qin He, Zhirong Zhang, Ling Zhang*. Journal of Controlled Release. 2020 Sep 10;325:10-24. doi: 10.1016/j.jconrel.2020.03.049.

2019：

1.Novel fibronectin-targeted nanodisk drug delivery system displayed superior efficacy against prostate cancer compared with nanospheres. Luyao Wang, Bingjie Zhou, Shiqi Huang, Mengke Qu, Qing Lin, Tao Gong, Yuan Huang, Xun Sun, Qin He, Zhirong Zhang, Ling Zhang*. Nano Research. 2019;12:2451–2459. doi:10.1007/s12274-019-2488-3

2.Polystyrene nanoparticles reduced ROS and inhibited ferroptosis by triggering lysosome stress and TFEB nucleus translocation in a size-dependent manner.Lin Li, Shili Sun, Lingli Tan, Yuanfang Wang, Luyao Wang, Zhirong Zhang, Ling Zhang*.Nano Letters. 2019 September 26;19(11):7781-7792. doi:10.1021/acs.nanolett.9b02795

3.Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of Imperialine. Qing Lin, Mengke Qu, Hirak K Patra, Shanshan He, Luyao Wang, Xun Hu, Linyu Xiao, Yu Fu, Tao Gong, Qin He, Ling Zhang*, Xun Sun and Zhirong Zhang. Journal of Controlled Release, 2019 October; 311–312:104-116. doi:10.1016/j.jconrel.2019.08.037

4.Target delivering paclitaxel by ferritin heavy chain nanocages for glioma treatment. Wei Liu, Qing Lin, Yu Fu, Shiqi Huang, Chengqi Guo, Lin Li, Leilei Wang, Zhirong Zhang, Ling Zhang*. Journal of Controlled Release, In Press. doi:10.1016/j.jconrel.2019.12.010

5.Therapeutic strategies for the costimulatory molecule OX40 in T-cell mediated immunity. Yu Fu, Qing Lin, Zhirong Zhang*, Ling Zhang*. Acta Pharmaceutica Sinica B. 2020 March;10(3):414-433. doi:10.1016/j.apsb.2019.08.010

6.Mechanistic and therapeutic study of novel anti-tumor function of natural compound imperialine for treating non-small cell lung cancer. Qing Lin, Mengke Qu, Shanshan He, Luyao Wang, Xun Hu, Linyu Xiao, Yu Fu, Tao Gong, Xun Sun, Qin He, Ling Zhang*, Zhirong Zhang. Journal Ethnopharmacology. 2020 Jan 30;247:112283. doi: 10.1016/j.jep.2019.112283

2018：

1.A brain targeting functionalized liposomes of the dopamine derivative N-3,4-bis(pivaloyloxy)-dopamine for treatment of Parkinson's disease. Qu M, Lin Q, He S, Wang L, Fu Y, Zhang Z, Zhang L. J Control Release. 2018 May 10;277:173-182. doi: 10.1016/j.jconrel.2018.03.019.

2.A novel α-enolase-targeted drug delivery system for high efficacy prostate cancer therapy. Wang L, Qu M, Huang S, Fu Y, Yang L, He S, Li L, Zhang Z, Lin Q, Zhang L. Nanoscale. 2018 Jul 19;10(28):13673-13683. doi: 10.1039/c8nr03297a.

3.Erythrocyte-membrane-camouflaged nanoplatform for intravenous glucose-responsive insulin delivery. Fu Y, Liu W, Wang L, Zhu B, Qu M, Yang L, Sun X, Gong T, Zhang Z, Lin Q, Zhang L. Adv Functional Materials. 2018 August 26. Doi: 10.1002/adfm.201802250.

4.Liver-Targeted Co-delivery of Entecavir and Glycyrrhetinic Acid Based on Albumin Nanoparticle To Enhance the Accumulation of Entecavir. He S, Lin Q, Qu M, Wang L, Deng L, Xiao L, Zhang Z, Zhang L. Mol Pharm. 2018 Sep 4;15(9):3953-3961. doi: 10.1021/acs.molpharmaceut.8b00408.

5.Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease. Qu M, Lin Q, Huang L, Fu Y, Wang L, He S, Fu Y, Yang S, Zhang Z, Sun X, Zhang L. J Control Release. 2018 October 10;287:156-166. Doi: 10.1016/j.jconrel.2018.08.035.